Efficacy of Montmorillonite Clay (NovaSil PLUS) for Protecting Full-Term Broilers from Aflatoxicosis
نویسندگان
چکیده
Contamination of poultry feeds by aflatoxin is a problem faced by poultry producers at one time or another. Of the several strategies used to reduce the economic effect of aflatoxincontaminated feeds, the inclusion of selective enterosorbents may be the most practical and cost effective. This study evaluated the effectiveness of montmorillonite clay (MC) supplied as NovaSil PLUS on the performance of full-term commercial type broilers. Eight hundred male commercial broiler chickens (all vaccinated for Marek’s disease, Newcastle disease, and bronchitis) were randomly assigned, (20 each) to 40 floor pens and fed 1 of the 4 dietary treatments of industrytype corn-soy broiler diets. Treatments consisted of a control feed, control feed plus 0.5% MC (CMC), a feed containing ∼4,000 ppb aflatoxin (AF), and a feed containing ∼4,000 ppb aflatoxin plus 0.5% MC (AMC). The starter diet was fed for 3 wk, the grower for 2 wk and, the finisher for 1 wk. Selected birds were randomly retained for specific tissue analyses of blood serum; relative liver, spleen, and kidney weights; and histological examination of sampled organs. The combined data showed that birds fed MC as NovaSil PLUS received significant protection against the effects of the aflatoxin for most parameters measured. This level of protection did not totally protect the birds from the effects of feeding extremely high concentrations of aflatoxin, however, as their performance was not as good as that of the control group. To our knowledge this is the first study addressing the protective effects of MC in full-term broilers fed steam-pelleted feeds more nearly approximating commercial production.
منابع مشابه
Aflatoxin-induced toxicity and depletion of hepatic vitamin A in young broiler chicks: protection of chicks in the presence of low levels of NovaSil PLUS in the diet.
Aflatoxin contamination of foods and livestock feeds is an ongoing problem. In this research, NovaSil PLUS (NSP), a calcium montmorillonite clay that is commonly used as an anticaking agent in feeds, was evaluated for its ability to bind aflatoxin B1 (AfB1) in vitro and to prevent the onset of aflatoxicosis and vitamin A depletion in broiler chicks in vivo. Isothermal analyses were conducted wi...
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NovaSil clay (NS) provides significant protection from the adverse effects of aflatoxins (AFs) in multiple animal species by decreasing bioavailability from the gastrointestinal tract. It is postulated that NS clay can be safely added to human diets to diminish exposure and health risks from AF contaminated food. To determine the safety and tolerance of NS in humans and establish dosimetry prot...
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Aflatoxin B1 (AFB1) is a potent carcinogen that causes growth stunting, immunosuppression and liver cancer in multiple species. The recent trend of replacing fishmeal with plant-based proteins in fish feed has amplified the AFB1 exposure risk in farm-raised fish. NovaSil (NS), a calcium montmorillonite clay, has previously been shown to reduce AFB1 bioavailability safely and efficaciously in se...
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A 3-month double-blind and placebo-controlled, phase IIa clinical trial was conducted in Ghana to investigate the safety, tolerance and aflatoxin-sorption efficacy of dietary NovaSil (NS). Volunteers (507 subjects) were clinically screened to evaluate their general health, pregnancy status and blood AFB(1)-albumin adduct levels. Of these subjects, 177 were randomly assigned to three groups: hig...
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